Category: Bioinformatics Workflows, Pipelines and Tools

Ensemble Feature Selection for Robust Multi-Omics Biomarker Discovery A Systems-Level Approach to Biomarker Discovery Abstract Biomarker discovery often suffers from instability — different feature selection algorithms produce different gene lists, reducing reproducibility and clinical trust. This project addressed that challenge by designing and implementing a comprehensive ensemble feature selection framework that integrates multiple ranking strategies…

Benchmarking Germline and Somatic Variant Calling Pipelines Using CoSAP and Galaxy A Comparative Study with 9 Pipelines on Real Exome Data Abstract This project evaluated nine variant calling pipelines using whole exome sequencing (WES) data. It involved combinations of two mappers (BWA, Bowtie2) and four variant callers (DeepVariant, HaplotypeCaller, Strelka, SomaticSniper) across both germline and…